1. A 23-year-old asymptomatic male👴 participates in clinical research📃 and is found to be homozygous for the apolipoprotein E-4 allele.  In the future, this patient is most likely to suffer from which of the following🤔?

2. A 75-year-old man👴 with alcoholism🍷 is brought to the emergency department 🏬 30 minutes after he began vomiting blood🩸. He has a history of portal hypertension. Abdominal examination shows spider angiomata. Which of the following is the most likely cause of this patient's hematemesis🤔?

3. A 27-year-old woman comes to the office for a health maintenance examination.  The patient has no chronic medical conditions and no family history of cancer.  She has had several sexual partners and takes oral contraceptive pills for birth control.  Vital signs are normal.  Physical examination, including pelvic examination, is normal.  A Pap test is performed and shows a squamous intraepithelial lesion that is positive for human papillomavirus.  A cervical biopsy is performed and reveals low-grade dysplasia.  Which of the following features best distinguishes this patient's lesion from cervical malignancy?

4. A 62-year-old man👨‍💼 comes to the office🏥 for follow-up🩺.  The patient has a 10-year history of type 2 diabetes mellitus.  Over the past 2 years, he has had burning pain and pins and needle💉 sensations in his feet👣, which is worse at nighttime🌃.  Nortriptyline💊 was prescribed, and the dosage was gradually increased📈.  Currently, the patient👨‍💼 takes the maximal recommended dose but states the symptoms are not well controlled.  He reports no drug adverse effects  Other medical history🩺 includes hypertension⚡ and hyperlipidemia  Blood pressure is 124/70 mm🩺 Hg and pulse is 68/min💓.  Physical examination 🩺 shows decreased light touch and pain sensation in the feet🐾.  Ankle reflexes are decreased📉 bilaterally.  His most recent hemoglobin A1c level is 7.0%🩸.  Appropriate foot care is advised, and additional pharmacotherapy💊 for the patient's symptoms is planned.  Which of the following medications⚕️ would provide additional benefit through a different mechanism with no drug-drug💊 interaction🤔?